The onset of corns is due to localized long-term friction and extrusion caused by skin conical growths. Clinical liquid nitrogen cryotherapy for corns has certain efficacy. The therapeutic mechanism of liquid nitrogen cryotherapy for corns is that the low temperature of liquid nitrogen acts on the tissues, causing the formation of ice crystals inside and outside of the tissue cells, resulting in the rupture of cell membranes and death of cells; the low temperature leads to edema and necrosis of the endothelium of the blood vessels, slowing down of the local blood flow and formation of thrombus, which results in the ischemia of local tissues and causes the coagulation and necrosis of the tissue cells. In addition, corns can also choose other treatment methods such as topical drugs, surgical excision, etc. Patients should be standardized under the guidance of the doctor to treat corns.