High-grade epithelial neoplasia of part of colon polyp is the result of pathological examination, and it may be a sign of precancerous lesion of part of colon polyp. Partial high-grade epitheliomatosis of colon polyps indicates that the part of colon polyps has pre-malignant manifestations, that is, pre-cancerous lesions, and should be actively treated, if not actively treated, there is a possibility of malignant transformation and the formation of malignant tumors. Colonic polyps part of high-grade epithelial neoplasia, it is recommended to take timely surgery, such as endoscopic resection of local lesions. Tissue examination is performed after resection, and if there is invasive carcinoma component, in addition to surgery, radiotherapy, chemotherapy and other therapeutic measures should be taken. If it is only a simple high-grade epitheliomatous lesion it is usually a routine surgery, and regular postoperative review is sufficient.