Artificial total knee replacement technique is currently the best mainstream approach for the treatment of end-stage knee diseases such as osteoarthritis, rheumatoid arthritis, and traumatic arthritis. And artificial total knee replacement operated using minimally invasive approach can greatly improve the speed of postoperative functional recovery, reduce perioperative blood transfusion and pain, with significant difference compared to conventional replacement techniques. On February 18, 2016, Professor Haining Zhang of the Department of Joint Surgery, Orthopaedic Medical Center, Qingdao University Hospital, successfully performed the first total knee arthroplasty with a modified subtrochanteric approach with a minimally invasive CS intra-axial type II EvolutionTM Easy NTM system in Shandong Province, using this minimally invasive approach to protect all quadriceps fibers and provide a total knee arthroplasty for a patient with a BMI of 31 (25 or more is considered obese) within a surgical incision of only 9 cm. A total knee arthroplasty was performed in a female patient with a BMI of 31 (25 or more is considered obese) within a 9 cm incision. Intraoperatively, the affected limb could be flexed up to 135°, and the quadriceps muscle strength could be restored quickly because the knee extension device was well protected, and the ability to raise the straight leg and walk on the ground could be restored 12 hours after surgery, and the incidence of postoperative pain and blood transfusion was reduced, which accelerated the recovery and enhanced the patient’s recovery confidence and satisfaction. According to Prof. Zhang, the CS ACL Replacement Knee Prosthesis is a new second-generation internal axial total knee system with a unique spacer design that replaces the anterior and posterior cross function, providing better stability and higher mobility, closer to normal knee motion mechanics, and therefore lower wear rate. The system is also more precise and convenient in osteotomy, facilitating intraoperative fine-tuning and allowing for millimeter-level precision in artificial total knee replacement surgery. The smaller size of the instruments facilitates minimally invasive surgery; the intercondylar osteotomy volume is lower and more bone is retained. As a representative of the new generation of total knee joint, it will benefit a wider range of patients.