Checking for H. pylori after taking antibiotics has an impact and may lead to a false negative result. Antibiotics such as penicillins such as amoxicillin, cephalosporins such as cefixime, aminoglycosides such as streptomycin, macrolides such as erythromycin, and tetracyclines such as tetracycline, all of these antibiotics may kill H. pylori and give false-negative H. pylori test results. Therefore, the H. pylori test should be performed after 1 month after stopping antibiotics to avoid affecting the test results. It is recommended that patients who need to undergo H. pylori testing should go to a regular hospital, consult with a doctor and complete the test under the doctor’s guidance.