Whether eating crabs can cause rhabdomyolysis depends largely on whether it leads to bacterial or viral infections, for example. If no infection occurs from eating crabs, it usually does not cause rhabdomyolysis; if an infection occurs, it may cause rhabdomyolysis. Rhabdomyolysis is the result of multiple etiologies of muscle necrosis and release of substances from myocytes into the bloodstream. The main clinical manifestations are muscle pain, weakness and dark-colored urine due to myoglobin, elevated creatine kinase in the blood, and in severe cases, electrolyte disorders and acute kidney injury may occur. There are many causes of rhabdomyolysis, such as muscle injury caused by strenuous exercise, trauma, extrusion, prolonged compression position or local ischemia, drug or bacterial infection, hereditary myopathy and inflammatory myopathy, hypokalemia and so on, all of which may cause rhabdomyolysis. Therefore, rhabdomyolysis usually does not occur if eating crabs does not lead to bacterial or viral infections; if eating crabs leads to bacterial or viral infections, rhabdomyolysis may occur. If a patient develops rhabdomyolysis, it is recommended that he or she should go to a regular hospital in time for consultation and targeted treatment or therapy under the guidance of a doctor.