The pain on both sides of the chest when pressed may be caused by muscle strain, pleurisy and breast hyperplasia. 1. Muscle strain: In daily life, improper exertion or prolonged repetition of the same position may cause local muscle strain, resulting in pain when pressed on both sides of the chest. 2. Pleurisy: it refers to the inflammatory reaction of the pleural tissue covering the lungs and chest wall, which is manifested as obvious pain when pressing on the chest. 3. Breast Hyperplasia: patients with imbalance of endocrine hormone metabolism and increased level of estrogen, resulting in the development of breast lumps, which will cause obvious pain when pressing the chest. When the patient presses the chest and there is pain, it is recommended to go to the hospital in time for examination and diagnosis, and under the guidance of the doctor to carry out the corresponding treatment.