Abstract OBJECTIVE: To investigate the clinical efficacy of Nexgen-LPS-Flex artificial knee replacement in the treatment of severe degenerative osteoarthropathy of the knee. Methods: We retrospectively analyzed the clinical outcomes of 126 patients (173 knees) with severe degenerative knee osteoarthropathy who underwent Zimmer High Flexion Posterior Stabilization (Nexgen-LPS-Flex) knee replacement from December 2003 to December 2009, and analyzed the clinical outcomes using the HSS scoring criteria. RESULTS: The average follow-up was 19 months (12-36 months). 126 cases of 173 knee replacements were operated successfully, with an average operation time of 78.2±13.5 minutes per knee. 4 cases (4 knees) had impaired incision healing; 3 cases of deep vein thrombosis in the lower limbs were diagnosed, and all of them were discharged from the hospital with interventional therapy; 1 case had a lagging extension of the knee, with no neurovascular injuries, and there were no complications, such as infection, fracture, loosening of prosthesis, dislocation, and so on. There was no infection, fracture, prosthesis loosening, dislocation and other complications. The femoral tibial angle was 5-7° of valgus, and the range of motion of the joint was (78.4±10.6)° preoperatively and (112.8±18.6)° postoperatively.173 The average HSS score of the knee was (32.4±12.0) before the operation, and (87.9±10.9) at the time of discharge from the hospital, which was significantly higher than that of the knee before the replacement (P < 0.01). CONCLUSION: The early clinical effect of Nexgen-LPS-Flex artificial knee replacement for severe degenerative osteoarthropathy of the knee was satisfactory, and no complications such as osteolysis, loosening of the prosthesis and severe wear of the liner were found in the early stage. Hu Ruyin, Department of Orthopedics, Guizhou Provincial People's Hospital