Many patients find that liver cancer is already in advanced stage after liver examination in the hospital, which is a very normal phenomenon. Doctors think that liver cancer in early stage usually has no symptoms and is hard to be diagnosed. Then when liver cancer is in advanced stage, the cancer cells have spread, what symptoms do patients have at this time? See the specific analysis below. Proliferation and metastasis of advanced liver cancer is one of its characteristics, which also indicates that the cancer is worsening, and the ways of proliferation mainly include: direct infiltration, bloody metastasis, lymphatic metastasis and implantation metastasis. Liver cancer advanced diffusion metastasis is dominated by hematogenous dissemination, which is mostly seen in advanced patients, about 50-70% of which are transferred to lungs, followed by adrenal glands, bones, brain, kidney and so on. Lymphatic metastasis to hilar lymph nodes is the most common, and cholangiocellular hepatocellular carcinoma has most lymphatic metastasis, and symptoms such as jaundice and cancerous fever may appear earlier. Hepatocellular carcinoma cells spread through blood pressure and cells, and can easily reach lungs and cause lung cancer, which may cause chest pain, cough, hemoptysis, breathlessness and other symptoms. Hepatocellular carcinoma also and to metastasize to pleura, forming pleural effusion, the patient feels breath, pleural fluid like blood, and cancer cells can be found in it. When liver cancer patients find respiratory symptoms such as chest pain, cough, etc., they should highly suspect lung metastasis of liver cancer, and they can take chest radiographs, do CT, and if there is pleural fluid, they should also do thoracocentesis to extract pleural fluid for laboratory tests.