Liver-protective and enzyme-lowering drugs can be used to lower transaminases. The drugs with better enzyme-lowering effects are glycyrrhetinic acid preparations, including diammonium glycyrrhizate, glycyrrhizin, magnesium isoglycyrrhizate, etc., and dicyclomine are also liver-protective and enzyme-lowering drugs. Drugs that nourish the liver include polyenyl phosphatidylcholine, which protects liver cell membranes and promotes cell membrane repair, and reduced glutathione, which is a drug for detoxification and maintaining liver cell function. The above drugs are the more widely used and effective liver-protecting and enzyme-lowering drugs in clinical practice. We also need to treat the causes of elevated transaminases, such as antiviral treatment for viral hepatitis, alcoholic hepatitis to stop drinking, and drug-related liver injury to stop taking drugs.