28mmx20mm strong echogenic nodule in the left lobe of liver needs further examination, which may be hemangioma, hepatocellular carcinoma, calcified foci, intrahepatic bile duct stone, etc. 1. Hemangioma: further examination such as abdominal CT, abdominal MRI can be done. If considered as hepatic hemangioma, it is a benign lesion, and if the nodule is small, it can be followed up regularly; if the nodule is large, it can be evaluated by doctor and then treated by surgery. 2. Hepatocellular carcinoma: further improve carcinoembryonic antigen and liver function tests, and if necessary, perform puncture to clarify the nature of the nodule. If malignancy is considered, the treatment should be actively standardized. 3. Calcified foci: If calcified foci are considered, there is no need for special treatment, and regular follow-up as prescribed by doctor is sufficient. 4. Intrahepatic bile duct stones: generally asymptomatic people do not need special treatment, if there are symptoms, it is recommended to go to the hospital, and the specialist will decide whether to non-surgical treatment or surgical treatment. It is recommended to actively consult the doctor, improve the relevant examination, and standardize the treatment after a clear diagnosis.