Headache powder is a compound preparation of painkillers, mainly containing caffeine, acetaminophen and other ingredients. It’s okay to take some headache powder occasionally when you have a headache, but if patients with long-term headache take headache powder frequently, it may lead to liver and kidney function damage, drug dependence and addiction, gastric mucosa damage and other side effects. 1. Liver and kidney function damage: because the drug needs to be metabolized by liver and kidney, so long-term or large amount of headache powder will increase the burden on the liver and kidney, and in serious cases, liver and kidney disease will occur. 2. Drug dependence and addiction: this medicine can relieve the phenomenon of mild to moderate pain caused by the disease, and when the patient consumes a large amount of it, drug dependence and addiction may be formed, which is not conducive to the treatment of the disease. 3. Damage to gastric mucosa: As headache powder contains caffeine, acetaminophen and other ingredients, large amounts of intake is prone to stimulate or damage the mucosa of the stomach, thus inducing gastric ulcers or gastric bleeding and other diseases. Drugs need to be reasonably applied under the guidance of a doctor.