Quadruple therapy is commonly used to eradicate Helicobacter pylori, in which bismuth and proton pump inhibitors (referred to as PPIs) are usually taken before meals, and antibiotics are taken after meals, usually twice a day for 10 to 14 consecutive days. Quadruple therapy has four medications, meaning one bismuth + one PPI + two antibiotics. The bismuth and PPI need to be taken before meals, and the antibiotics are taken after meals, and usually need to be taken twice a day for 10~14 consecutive days. Commonly used bismuth agents are bismuth pectin and bismuth potassium citrate, etc. Commonly used antibiotics are clarithromycin, metronidazole, tetracycline, amoxicillin, etc. Commonly used PPIs are omeprazole and rabeprazole. If adverse reactions such as allergy, nausea and vomiting occur during the use of quadruple therapy, you should consult the doctor in time and adjust the treatment program under the doctor’s guidance. If allergic to one of the drugs should not be used, children should be careful to choose drugs. The specific method of medication should be under the guidance of the doctor according to the specific circumstances. After the quadruple therapy treatment, regular review should be conducted under the guidance of the doctor. Usually pay attention to a light diet, avoid hot pot, alcohol and other stimulating foods.