Diabetic patients combined with serious complications are mainly the following cases, such as combined with serious nephropathy, reaching a large amount of proteinuria, or even combined with abnormal kidney function and uremia. In this case, in addition to controlling blood sugar with insulin, taking drugs to protect the kidneys and reduce urine protein, dialysis treatment should be taken if necessary. If the combined diabetic retinopathy is within three stages, it can be treated with medication. If it is in the latter three stages, intra-bulbar drug injection or laser treatment may be considered.