Occasionally staying up late may not have significant harm to kidney function, but long-term staying up late may aggravate the burden on the kidneys, especially for patients with renal insufficiency, which is more harmful. Kidney is the detoxification organ of human body, if stay up late for a long time, it may aggravate the burden of kidney and lead to the accumulation of metabolic waste and toxins in the body; and kidney as one of the important organs of human body, blood supply is very rich, blood flow is large, long-term stay up late can damage blood vessels, resulting in kidney blood supply problems. Therefore, especially for patients with renal insufficiency, staying up late may aggravate the damage of renal function. Long-term staying up late may also lead to the decline of immunity, which may easily aggravate the infection, etc. It is recommended that patients pay attention to rest in daily life, especially patients with renal insufficiency try to avoid staying up late to prevent aggravation of the condition. If the patient has kidney function damage, it is recommended to go to the regular hospital in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or treatment under the guidance of the doctor.