The causes of high γ-glutamyltransferase include liver disease, biliary tract obstructive disease and so on. 1. Liver diseases: such as acute and chronic viral hepatitis, acute and chronic alcoholic hepatitis, cirrhosis, drug-induced liver injury, fatty liver and so on, can cause high γ-glutamyltransferase. 2. Biliary tract obstructive diseases: chronic cholestasis caused by various reasons, such as sclerosing cholangitis, primary biliary cirrhosis, etc., can lead to high γ-glutamyl transferase. 3. Others: such as pancreatitis, pancreatic tumor, prostate tumor, etc., can also cause high γ-glutamyltransferase. There are many other reasons for high gamma-glutamyltransferase, which should be emphasized, and timely consultation should be made to identify the cause of the disease, and further treatment should be provided according to the doctor’s instructions.