HPV52 positive need to do colposcopy, in the case of no problem can play quadrivalent cervical cancer vaccine. HPV52 positive indicates that there is high-risk HPV infection, need to do colposcopy to find out whether there are lesions on the epithelium, in the absence of lesions can be regularly rechecked, some patients will turn negative, a small number of patients will be persistently infected, if there is no problem with the colposcopy, it will not affect the quadrivalent cervical cancer vaccine. Quadrivalent vaccine is mainly to prevent HPV6, HPV11, HPV16, HPV18 infection, and the cause of cervical cancer in Asian women is mainly caused by HPV16, HPV18 in the cervix persistent infection caused by the vaccine, so it is necessary to vaccinate quadrivalent vaccine, but there is no conflict with the HPV52 positive, so you can vaccinate quadrivalent vaccine. The precautions after vaccination are to take a light diet, try to avoid eating some spicy and stimulating food, and pay more attention to rest, avoid overwork of the body, the vaccination site should not get wet too early, but also to closely observe the body’s symptomatic manifestations as well as body temperature changes.