Elevated blood creatinine after right nephrectomy requires active improvement of urine routine, 24-hour urine protein quantification, related antibodies, blood glucose and other tests to exclude primary glomerulonephritis, secondary nephropathy and so on. After unilateral nephrectomy, if the function of the opposite side of the kidney is normal, the creatinine will not be elevated. Once the creatinine is elevated, primary glomerulonephritis and secondary nephropathy such as diabetic nephropathy and hypertensive nephropathy should be excluded. At this time, it is necessary to improve the urine routine, 24-hour urine protein quantification, urine protein spectrum, related antibodies (anti-nuclear antibody, anti-double-stranded DNA antibody, etc.), fasting blood glucose, etc. If the diagnosis of nephropathy, it is necessary to reduce urinary protein, lower blood pressure, lowering glucose and other treatments, and if necessary, immunosuppressive therapy. If the above diseases are excluded, it is considered that unilateral kidney has not been fully compensated, usually pay attention to low-salt, high-quality and low-protein diet, avoid the application of drugs that have damage to the kidney, and regularly review the renal function. It is recommended to go to the hospital in time, follow the doctor’s instructions to improve the examination, clarify the cause of the disease and standardize the treatment.