Creatinine 173μmol/L is generally not serious if it belongs to physiologic increase; if it belongs to pathologic increase caused by acute kidney injury, it is generally not serious; if it is chronic increase, if it is not treated, it may eventually lead to uremia, which is more serious. 1. Physiological elevation: generally not serious, without special treatment. Such as after strenuous exercise, eating a lot of meat food, emotional stress and anxiety, etc., may lead to high creatinine, but physiological factors caused by high creatinine will not affect the renal function, affecting renal excretion, so it is not serious, but it is recommended to review regularly to assess the renal function. 2. Pathological increase (1) If creatinine 173μmol/L is pathologically elevated, the excretion of renal function has been changed. If the increase is acute, such as diarrhea, infection and other transient increase in creatinine, after removing the cause of the disease and symptomatic treatment, it can usually be recovered, so it is not serious. (2) If the creatinine is elevated chronically, i.e. chronic renal failure, it is more serious, and if not treated in time, further aggravation of the condition may also develop into uremia. If creatinine index is high, it is recommended to go to the hospital regularly to check the renal function, to know the damage of renal function, and once abnormalities are found, you should strictly follow the doctor’s instructions to carry out regular treatment.