The standard value of 24-hour urine protein does not exceed 150 mg, and 24-hour urine protein of 380 mg has exceeded the normal range. If the proteinuria is elevated due to physiologic factors, the proteinuria is temporary and not considered serious. If proteinuria occurs in urologic diseases caused by pathological factors, proteinuria may be serious at this time. 1. Physiological factors: physiological causes are common in strenuous exercise, fever, chills, nervousness, sympathetic nervous excitement and the use of vasoactive drugs, or postural proteinuria that occurs in thin and tall body type adolescents. There is no substantial renal damage due to physiological factors, and the proteinuria quantification can be normalized after removing the triggers or restoring the body position. 2. Pathological factors: commonly found in urological diseases such as primary or secondary glomerular disease, tubulointerstitial disease, etc., when the glomerular selective filtration structure is destroyed, or the proximal tubular function is impaired, protein filtration, absorption obstacles. It can also be seen in plasma protein concentration is too high, exceeding the tubular reabsorption capacity, when proteinuria may be severe. If the test result is 24-hour urine protein 380 mg, patients should not judge or diagnose on their own based on one test result, they should promptly consult the doctor to improve the glomerular function test, renal tubular function and other tests, to make a clear diagnosis under the assessment of a professional physician, and to actively treat the disease.