High levels of anti-mutant citrullinated wave protein antibodies are usually considered to be associated with rheumatoid arthritis, but should be considered in conjunction with physical symptoms and signs. Anti-mutant citrullinated wave protein antibody is a target substance for rheumatoid arthritis screening, so the presence of rheumatoid arthritis should be considered after a significant increase in the number of antibodies. However, a single test result cannot directly confirm the diagnosis, so it is necessary to check whether there is joint swelling and pain, dyskinesia, and so on, to confirm the diagnosis. After the presence of high anti-mutant citrullinated wave protein antibody or the diagnosis of rheumatoid arthritis, anti-inflammatory and immune system treatments should be carried out in a timely manner, which can help to alleviate the discomfort and joint damage caused by rheumatoid arthritis, and in severe cases, surgical procedures may also be used to quickly remove the joint lesions and promote the health of the joints. When the test results show an increase in anti-mutant hypergammaglobulin antibodies or other abnormalities, it is recommended that further examination be conducted in a timely manner and appropriate treatment options be selected under the guidance of a physician.