Many people ask this question, what are the main aspects of low platelets? There are three main aspects of low platelets: First, reduced platelet production or ineffective death, including both hereditary and acquired. Acquired reduced platelet production is caused by certain factors, such as drugs, malignancies, infections, ionizing radiation and other damage, hematopoietic stem cells or affect their proliferation in the bone marrow, which can affect multiple hematopoietic cell systems, often accompanied by varying degrees of anemia, the leukopenia, and a marked decrease in bone marrow megakaryocytes. Second, there is excessive destruction of platelets, including, for example, congenital and acquired cysts. Acquired excessive platelet destruction includes immune and non-immune, immune excessive platelet destruction commonly includes idiopathic thrombocytopenic purpura and pharmacological thrombocytopenia, non-immune excessive platelet destruction includes infection, diffuse intravascular coagulation, thrombotic thrombocytopenic purpura and so on, all of which can lead to excessive platelet destruction and cause low platelet count. Thirdly, it is excessive retention of platelets in the body, commonly in hypersplenism, so splenectomy is one of the methods to treat thrombocytopenia. For such patients with hypersplenism, when platelets are found to be low, they must go to the hospital in time to clarify the cause of thrombocytopenia and treat it in time.