Uneven bone density usually suggests the following situations: First, degenerative osteoarthritis: such as knee joints and other lower limb weight-bearing joints, when serious degeneration occurs, osteoarthritis will be formed, and there will be obvious uneven bone density within the bone under the articular surface, and even localized cystic degeneration and bone necrosis. Patients will show joint pain, swelling, limited activities, even when resting, there will still be pain symptoms, which can be confirmed by X-ray and MRI. Secondly, osteoporosis: with the aging of the elderly patients, the bone strength will decrease, the bone quality is prone to osteoporosis, and the X-ray film will show uneven bone density. In serious cases, pathological fracture will occur, and at the same time, there are symptoms of generalized bone and muscle pain. If there is uneven bone density, early diagnosis and early treatment can lead to significant relief of clinical symptoms, and patients should usually increase nutrition and exercise appropriately.