Proteinemia should be referred to here as hyperimmunoglobulinemia, and hyperimmunoglobulinemia combined with sternal flashing pain is not necessarily multiple myeloma. It may be caused by the same disease or by a different disease. Hyperimmunoglobulinemia is a condition in which plasma cells proliferate abnormally for some reason. Sternal pain is often indicative of bone destruction. Common causes of hyperimmunoglobulinemia include primary macroglobulinemia, multiple myeloma, and heavy chain disease. 1. Primary macroglobulinemia: it is a malignant tumor of the lymphatic system. Due to excessive proliferation of lymphocytes, it leads to monoclonal immunoglobulinemia, as well as anemia, highly enlarged lymph nodes, liver and spleen, etc. There may be no bone destruction. 2. Multiple myeloma: myeloma cells secrete monoclonal immunoglobulin, normal synthesis of polyclonal immunoglobulin is inhibited, and monoclonal immunoglobulin appears in serum or urine, accompanied by anemia, renal failure and bone damage. A large number of plasma cells can be detected in the bone marrow. 3. Heavy Chain Disease: It often shows disseminated lymphocytic, plasma cell, basophilic granulocyte and reticulocyte infiltration, but does not cause bone damage. It may show generalized lymph node enlargement and highly enlarged liver and spleen. Other diseases that cause bone pain and bone destruction include metastatic bone cancer, senile osteoporosis and hyperparathyroidism. Therefore, the combination of hyperimmunoglobulinemia and sternal pain is not necessarily multiple myeloma, but may also have other causes, and should be consulted in time, so that the doctor can give a clear diagnosis, and actively cooperate with the doctor’s treatment.