Ar-He knife is not really a scalpel, it is a minimally invasive technology that can percutaneously remove diseased tissues from the body. This argon helium knife system, which adopts several U.S. space rocket guidance technologies and more than ten European and American patents, is the world’s first and only medical system with dual efficacy of ultra-low temperature freezing and thermal therapy, bringing a new breakthrough and development to the treatment technology of tumors. Under the guidance of CT or B-ultrasound, 4-8 superconducting needles with temperature difference coupling monitoring are selected and positioned directly and accurately to penetrate into cancerous tumor tissues, and after reaching the lesion, through the conversion of argon and helium, the cancerous tumor tissues are frozen into ice balls within a few minutes, so that the local temperature at the lesion drops to minus 195 degrees (-195℃) and ice crystals are formed rapidly inside and outside the cells, which causes the tumor cells to rupture and completely destroy the tumor cells. The tumor cells are ruptured, completely destroying the tumor cells and tissue necrosis. At the same time, the necrotic cells can also stimulate the body to produce antibodies and improve immunity. Ar-He knife cryotherapy represents the most advanced level of international ultra-low temperature cryotherapy instruments in the 1990s, which has stimulated the revolution of ultra-low temperature surgery and cancer treatment. Ar-He knife has many unique advantages, such as no incision, no bleeding or less bleeding, slight surgical injury, less patient pain and fast recovery; high success rate and few complications; can be repeated; can be performed alone or combined with radiotherapy or vascular embolization therapy; significant effect and easy operation. Ar-He knife cryotherapy has a very wide range of solid tumors, such as liver cancer, lung cancer, sarcoma, bone metastases, soft tissue tumors, limb tumors, intracranial tumors, etc. It has enabled many otherwise unresectable tumors to be cured, greatly improving the survival quality and survival time of patients with advanced tumors. What’s more, because the argon helium knife cooling or heating is limited to the ultra-cooled knife tip and the knife rod has good thermal insulation, it will not damage the tissues in the puncture path. For early and middle stage tumors, it can achieve the effect of cure; for advanced stage tumors that press the surrounding organs, it can also be used as palliative treatment to reduce the tumor load, alleviate the pain and compression symptoms, improve the quality of life and prolong the survival time, which is a new idea and new method for clinical tumor treatment.