The hepatitis B major tri-positive accompanied by abnormal liver function is usually contagious, because the hepatitis B major tri-positive is generally active in viral replication, high viral amount is indicative of high contagiousness, but the specific size of the contagiousness, or through the hepatitis B virus DNA quantitative testing to determine. A hepatitis B major triple-positive accompanied by liver function abnormalities, then the need for treatment, it is recommended that the choice of entecavir, tenofovir, propofol tenofovir or interferon to treat the specific choice of which antiviral drugs, but also a comprehensive patient’s indicators to determine, but also for liver function abnormalities can also choose to protect the liver, lower transaminases drugs to assist in the treatment.