Extensive enterocolitis combined with H. pylori infection is useful to take antibiotics for H. pylori. Extensive intestinal chemosis in combination with H. pylori-negative gastritis does not require antibiotic treatment. Extensive enteric chemosis is the replacement of gastric mucosal epithelial cells with intestinal-type epithelial cells and is seen mainly in atrophic gastritis. Gastrointestinal epithelialization is closely related to Helicobacter pylori infection. So for intestinal epithelial chemosis with H. pylori infection to eradicate H. pylori, such as amoxicillin, clarithromycin, omeprazole and bismuth pectin capsule to kill H. pylori. Patients with extensive intestinal chemosis should pay attention to a light diet and avoid stimulating foods to avoid aggravating the condition. If intestinal chemosis becomes cancerous, aggressive surgical treatment is necessary. If extensive intestinal chemosis occurs, it is recommended to seek medical treatment in time to avoid delaying the condition, and the specific medication should be applied under the guidance of the doctor.