After total removal of the thyroid gland, there is no thyroxine secretion, so lifelong thyroxine replacement therapy is needed. The thyroid gland belongs to the endocrine system of the body, thyroxine is secreted by the thyroid gland to promote the body’s metabolism and maintain normal physiological functions, while other organs in the body cannot secrete thyroxine. Therefore, if the thyroid gland is completely removed, there is no organ that produces thyroxine, and the body has no self-produced thyroxine, so it is necessary to take exogenous thyroxine tablets for a lifetime instead of the treatment, in order to maintain the body’s normal physiological and metabolic functions. The specific dosage needs to be adjusted under the guidance of a professional endocrinologist, and the level of thyroxine in the body should be monitored to prevent hypothyroidism.