Levofloxacin does not work for UTIs, and patients are advised to change the sensitivity of the medication under the supervision of a doctor for treatment. Typically, non-specific urinary tract infections are often gram-negative bacteria, such as Escherichia coli and Aspergillus. Levofloxacin is often more effective against these types of bacterial infections. However, levofloxacin-resistant strains of bacteria often appear in the clinic, when the urethritis taking levofloxacin does not work, it is necessary to promptly under the guidance of the doctor to replace the other sensitive antibiotics for treatment. In addition, for some specific infections, such as gonococcal urethritis, mycoplasma, chlamydia caused by urethritis, sometimes there will be levofloxacin resistance, so the urethritis when taking levofloxacin does not work, it is recommended to communicate with the doctor in a timely manner to carry out the relevant examination, such as urine culture, according to the results of the selection of the appropriate drugs. To summarize, if the UTI drug treatment effect is not good, should be timely review.