The difference between non-invasive DNA and amniocentesis lies in the different testing methods, accuracy rates, gestational weeks and so on. 1. Detection method: Non-invasive DNA belongs to the prenatal screening method, which is to detect the probability of the fetus suffering from chromosomal abnormality by extracting venous blood from the mother. Amniocentesis is the gold standard of prenatal diagnosis, in which amniotic fluid is extracted under ultrasound guidance for further examination to determine whether the fetus is suffering from chromosomal abnormalities. 2. Accuracy: The accuracy rate of non-invasive DNA is more than 95%, and the accuracy rate of amniocentesis is more than 99%. 3. Pregnancy week: Non-invasive DNA is applicable to 13-22⁺⁶ weeks of pregnancy, while amniocentesis is usually recommended to be performed in 16-22 weeks of pregnancy. If a pregnant woman is at high risk for non-invasive DNA testing, it is recommended that she seek medical attention in a timely manner, and under the guidance of a doctor, go through a walk through amniocentesis to clarify the cause of the disease and symptomatic treatment.