Multiple myeloma mostly occurs in middle-aged and old people, and the early symptoms are bone pain, pathological fracture and anemia. Multiple myeloma is a malignant proliferative disease of plasma cells, mostly occurring in middle-aged and old people, with various symptoms. Early typical symptoms are intermittent bone pain, mostly occurring in lumbosacral region, thorax and limbs, followed by persistent and progressive aggravation. There are often different degrees of anemia (such as fatigue, pallor, etc.), renal insufficiency symptoms (such as edema, oliguria, hypertension, etc.). Due to bone destruction, pathological fracture, symptoms of hypercalcemia (e.g. headache, vomiting, polyuria, constipation, etc.), neurological symptoms (e.g. peripheral sensory nerve numbness), etc. may also occur. If the above symptoms are suspected to be multiple myeloma, the patient should seek medical treatment as soon as possible, and after the diagnosis is confirmed, the patient should be treated in a standardized manner.