N-terminal natriuretic peptide is a downstream substance that starts from the source when the heart is shocked by blood and the ventricular muscle is strained to secrete Pre-proBNP, which is metabolized into proBNP, and then sheared by endonuclease to form N-terminal proBNP and active BNP. NT-proBNP is N-terminal natriuretic peptide, which is of clinical significance. It is mainly used to diagnose and identify heart failure, and can also guide the efficacy of heart failure after treatment and evaluate the prognosis of heart failure.