The late stage of acute leukemia is already very serious and usually requires hospitalization for treatment to slow down the progression of the disease. 1. In general, the late stage of acute leukemia is very serious, and may manifest a series of symptoms such as granulocyte deficiency, high fever, generalized hemorrhage, petechiae and ecchymosis of the skin, dizziness, headache, nausea, vomiting, or even projectile vomiting, lowered blood pressure, and circulatory failure. 2. Although the condition of leukemia is very serious in the late stage, it is still possible to be cured after active and effective treatment, so it is best to be hospitalized. Treatment is mainly through blood transfusion, chemotherapy or hematopoietic stem cell transplantation. 3. Firstly, red blood cells and platelets are imported to increase the patient’s blood cell level and improve the symptoms of bleeding and anemia. Secondly, anti-leukemia treatment by using multi-drug combination chemotherapy. Finally, hematopoietic stem cell transplantation therapy is performed to rebuild the patient’s hematopoietic and immune functions, possibly eradicating the leukemia. In the late stage of acute leukemia, hospitalization is still recommended to actively cooperate with doctors for treatment in order to slow down the progression of the disease. If conditions permit, hematopoietic stem cell transplantation can be performed. Patients should maintain a good mood, pay attention to supplemental nutrition, moderate exercise and prevent infection.