Hard epididymal nodules usually cannot be rubbed away. There are many causes of epididymal hard nodules, which can be seen in cases of epididymal inflammatory nodules, tuberculous nodules, tumors, etc. Different causes have to be handled in different ways. 1. Inflammation of the epididymis, which can be manifested as epididymal hard nodules, cannot be rubbed away and is likely to lead to aggravation of the condition. Epididymal inflammation later nodules, there is no specific drug, may persist for a long time, do not need to intervene in the treatment. Antibiotics such as ceftriaxone can also be used for treatment, but is not limited to cephalosporins. 2. If it is tuberculous epididymal nodule, anti-tuberculosis treatment should be actively carried out, and the drugs include isoniazid, rifampicin and so on. 3. The treatment of epididymal tumor is mainly based on surgical resection, and when metastasis occurs, it can be combined with other treatment modes such as radiotherapy and chemotherapy. If there is epididymal nodule, should consult the doctor in time, all the above drugs need to pay attention to the side effects and adverse reactions of the drugs, please use under the guidance of the doctor.