Vaccination drink Sprite headache fever this situation may be caused by vaccination, fever is not necessarily caused by drinking Sprite. If you have a headache and fever after vaccination, it may be an adverse reaction to the vaccination and can be treated appropriately. Drinking Sprite after vaccination generally does not affect the effect of the vaccine or health, because the main component of the vaccine is the antigen, through the action of the immune system, to induce the production of antibodies. Sprite’s main ingredients include water, carbonic acid, sugar, etc. After drinking, it is mainly digested and absorbed through the gastrointestinal tract and metabolized through the urinary system, so it does not affect the immune system and does not cause fever. Adverse reactions to vaccination can be relieved on their own, and can be treated symptomatically with non-steroidal anti-inflammatory drugs (NSAIDs) such as acetaminophen and ibuprofen if necessary. If symptoms persist, it is recommended that you seek medical attention to identify the cause of the illness to avoid delays.