If the mouth is bitter at night when sleeping, the specific treatment includes diet regulation and exercise, oral care, etc., as follows: 1. Diet and exercise regulation: Do not eat late at night, and active oral treatment, you can drink some water properly, walk and stand properly before going to bed, try not to lie down all the time before going to bed, wait until it is time to sleep, the main purpose is to prevent bile reflux aggravation. 2, Oral care: for oral diseases to deal with, timely brushing and rinsing helps to avoid the symptoms of bitter mouth at bedtime due to oral infection factors. 3, treatment of the original disease: for patients with stomach disease, to give timely treatment and medication, but also to effectively avoid the symptoms of bitter mouth due to poor digestive function. Therefore, if you sleep with bitter mouth, you should actively improve for the above aspects and give medication if necessary to be able to control the symptoms.