Long-term use of gastric drugs have the following hazards: 1, decreased appetite: long-term use of acid suppressants, proton pump inhibitors, etc., so that gastric acid suppression for a long time, there will be a decrease in appetite, and the barrier function of gastric acid is reduced, easy to complicate gastrointestinal infections and other diseases, may also affect sexual function. 2, cause complications: the protection of gastric mucosa agents, such as bismuth, in the body tired will appear bismuth poisoning, causing brain and kidney damage, the emergence of 3, produce dependence: promote gastric power drugs, long-term use leads to drug dependence, when the drug is discontinued gastrointestinal function can not adapt, there will be gastrointestinal disorders, abdominal distension, belching and other performance. As the saying goes, medicine is toxic, and prolonged use of medicine will increase the burden on liver and kidney function. Be sure to take medication on time and as needed under the guidance of a doctor, and do not adjust the dosage and cycle of medication on your own.