Alkaline phosphatase 256U/L in children may be related to physiological factors or pathological factors, such as liver and gallbladder diseases, bone diseases and other factors, as analyzed below: 1. Physiological factors: During the physiological bone development period of children, the alkaline phosphatase 256U/L in the body is normal, because the alkaline phosphatase in children’s bone tissue is very active in this period, so it will be high. 2. Pathological factors: the above situation in children may be related to liver and gallbladder diseases such as bile duct stones and intrahepatic cholestasis, and may also be related to bone diseases such as rickets and osteochondrosis. Alkaline phosphatase 256U/L in children may have other causes, it is recommended to go to the hospital in time for relevant examinations, after clarifying the cause of the disease, active symptomatic treatment.