Herpes zoster pain relief is based on drug treatment, commonly used non-steroidal anti-inflammatory drugs, opioids, etc., in addition to anti-viral therapy for the disease itself. Herpes zoster is a skin disease caused by the varicella-herpes virus, usually caused by the reactivation of the latent virus in the body, and is mainly manifested by clusters of blisters distributed in bands on one side of the body. The disease can cause a significant painful sensation in the skin. For mild to moderate pain, analgesia can be provided with non-steroidal anti-inflammatory drugs such as ibuprofen and diclofenac sodium. For those with moderate to severe pain, pregabalin or gabapentin, or opioid analgesics such as morphine and oxycodone can be used. In addition to symptomatic treatment, it is also necessary to treat the virus itself. Commonly used antiviral drugs include acyclovir and ganciclovir, which can shorten the course of the disease and accelerate the healing of the rash. Specific medication varies according to the condition, and it is recommended that patients consult a doctor in a timely manner, use medication under the guidance of the doctor, and avoid self-medication.