Callus in medicine refers to callus, callus on the soles of the feet is very thick can be removed through general treatment, medication, physical therapy and other ways. 1. General treatment: patients with thick calluses on the soles of the feet should minimize friction or extrusion of the feet, and can often soak the affected area or use moisturizing creams and other products to help the skin become soft and moist, which will help the condition recover. 2. Medication: patients can follow the doctor’s instructions to use topical exfoliators such as sulfur salicylic acid ointment, retinoic acid ointment, etc., to help dissolve and remove the keratin, so as to remove the callus purpose. 3. Physical therapy: patients can also take liquid nitrogen freezing to treat callus, through the cold effect of tissue necrosis, help to remove callus. Laser treatment can also use the photothermal effect to gasify the callus, help to improve the symptoms of the foot. Thick callus on the soles of the feet removal method is more, it is recommended that patients go to the regular hospital, with the doctor for standardized treatment.