There is no “best” treatment option for category 4B breast nodules, and the appropriate option should be chosen based on the results of the biopsy, such as conservative, surgery, radiotherapy, etc. The BI-RADS classification of breast nodules is based on ultrasound and mammogram results to assess the risk of benign or malignant nodules. The BI-RADS classification of breast nodules is based on ultrasound and mammogram results to assess the risk of benign or malignant nodules. 4B nodules indicate moderate malignancy, with a probability of malignancy ranging from 10 to 50%, and puncture biopsy and other pathologic tests are recommended to further define the nature of the lesion. 1. If the lesion is confirmed to be breast cancer by puncture, the lesion should be further evaluated and treated with radical surgery (breast-conserving surgery or radical mastectomy + sentinel lymph node biopsy or axillary lymph node dissection), chemotherapy, endocrine therapy, radiotherapy, and other comprehensive treatments. 2. If fibroma or intraductal papilloma is confirmed by puncture, lumpectomy is also feasible. 3. If the puncture is confirmed to be cysts, breast hyperplasia, etc., the patient can not be operated, followed by observation and conservative treatment with drugs such as tamoxifen. It is recommended that the patient should consult the doctor for further examination to clarify the nature of the lesion and then follow the doctor’s instructions for active treatment.