Indications for guided bone regeneration include insufficient alveolar bone width, poor alveolar bone shape, bone windowing or bone cracking, and for thickening the labial bone plates of the anterior teeth to protect the teeth from loosening and gingival recession during orthodontic procedures such as PAOO, which is a surgical procedure in orthodontics. In general, whenever poor alveolar bone shape or bone loss occurs, the use of bone guided regeneration can be considered to restore the desired shape and physiological function of the alveolar bone. Contraindications for bone-guided regeneration are similar to those for periodontal tissue-guided regeneration. Firstly, periodontitis must be controlled, because patients with periodontitis have bacterial damage and toxin buildup on the alveolar bone, and if there are too many bacteria or toxins on the alveolar bone, the bone guided regeneration may fail. Therefore, periodontal inflammation must be controlled before performing bone tissue guided regeneration. Secondly, bone tissue guided regeneration is also not suitable if the person has been taking osteoporosis medication for a long time, such as bisphosphonates. It is usually safer to perform the procedure six months, or even a year, after stopping the medication. Because the metabolism of bone tissue will be inhibited in patients taking such drugs, after bone grafting, the bone powder will not be able to form bone, and even dead bone may occur, so it is not suitable for bone tissue guided regeneration surgery. In addition, patients who have received short-term radiotherapy or corresponding basic disease treatment, such as angina pectoris, myocardial infarction, cerebral infarction, or patients with implants, it is generally recommended to observe for half a year, and then carry out bone tissue-guided regeneration surgery after the vital signs or other diseases are stabilized.