There are many causes of itching on the inner walls of the urethra, mostly due to urinary tract infections, but the causes of itching on the inner walls of the urethra differ between men and women due to certain differences in their body structure. In women, it is mostly due to urethritis or vaginitis, and in men, it is mostly due to glansitis, but the possibility of STDs cannot be ruled out. Because of the proximity of the vagina to the urethra, if a woman has gynecological inflammation, such as the common vaginitis, it can easily lead to bacterial transmission to the urethra and thus inflammation. Stimulation by inflammatory factors can lead to itching on the inner walls of the urethra on both sides. Vaginitis can be treated with drugs such as metronidazole and clotrimazole to sterilize and reduce local inflammation. Urethritis is recommended to use ceftriaxone for intramuscular injection, and can also be treated with oral levofloxacin, ciprofloxacin, cefixime and other drugs. When a man has a long foreskin or hygiene problems, etc., it may lead to local breeding of bacteria, which can easily lead to glansitis. Patients are advised to keep the area clean and can use potassium permanganate solution for wet compresses, or they can take oral fluconazole, itraconazole or metronidazole for treatment. It is possible to undergo circumcision after the inflammation is controlled to avoid recurring episodes of glansitis. In addition, gonorrhea and genital herpes, can also cause itching on both sides of the inner wall of the urethra. Male gonorrhea patients may experience redness, itching, and mild tingling at the urethral opening at the beginning of gonorrhea infection. Female patients may also experience itching and redness of the urethral opening. However, other symptoms such as frequent, urgent, and painful urination with purulent discharge are more pronounced. Genital herpes may also present with itching on the inner two walls of the urethra, but it will mostly be accompanied by other lesions such as papules and blisters, and it is recommended that treatment be carried out strictly in accordance with medical advice.