Waking up at 4 a.m. may be related to physiological factors, or it may be due to phytoneurological disorders, depression and other causes, which can be alleviated through general treatment, psychotherapy, medication and other ways. 1. Physiological factors: because with age, the body’s melatonin secretion gradually decreases, so indirectly will affect the quality of sleep, the phenomenon of waking up at 4 am every morning. If there are problems with sleeping habits, such as going to bed too early every day, the phenomenon of waking up at 4:00 a.m. every morning can also occur. No special treatment is needed. 2. Phytoneurological dysfunction: usually caused by long-term poor living habits, emotional instability, etc., which can lead to neurological dysfunction and dysregulation of the autonomic nervous system, which will show the phenomenon of waking up at 4:00 in the morning. For this situation should improve the bad habits, regular work and rest, avoid staying up late, maintain emotional stability, if necessary, to assist in the treatment of drugs, such as ghrelin. 3. depression: the occurrence of this disease and genetic, neurobiochemical, psychosocial, neuroendocrine and other factors, often due to stressful life events stimulation, pessimistic personality, alcoholism and other factors and triggered, resulting in patients with early awakening, dreaming, sleep sense of the lack of sleep disorders, so there can be a 4:00 a.m. wake up symptoms, psychological treatment at the same time, can be assisted by paroxetine, lorazepam and other drugs to assist in the treatment. Wake up at 4:00 in the morning, may also be caused by other reasons, should be as early as possible to seek medical attention, clear cause of the disease, by the doctor under the guidance of treatment, do not blindly self-medication.