Megaloblastic anemia has been taking folic acid tablets and other medicines for ten months whether it is necessary to continue to take them is related to the condition. Generally, after the hemoglobin and red blood cells return to normal, you can stop taking folic acid, and the absorption of folic acid can be increased by eating green vegetables rich in folic acid. The drug treatment of megaloblastic anemia is mainly to supplement the required folic acid and vitamin B12, which should be taken according to the doctor’s prescription until the anemia completely disappears and the blood picture returns to normal. Vitamin C can promote the absorption of folic acid when taking oral folic acid, and iron can be added during the recovery period to prevent iron deficiency anemia. If nutritional megaloblastic anemia is caused by the use of antifolate metabolizing drugs, it can be treated with formyltetrahydrofolate. In case of vitamin B12 deficiency alone, folic acid should not be added to avoid aggravating neurological symptoms. Drugs should be used under medical supervision, avoid self-medication.