Herpes zoster, commonly known as “snake sores” and “spider sores,” is a viral skin disease caused by the herpes zoster virus, and is characterized by a cluster of herpes with neuralgia along the peripheral nerves. Some middle-aged and older patients, especially the elderly, often suffer from neuralgia, which is characterized by paroxysmal burning pain, and some of them still have persistent neuralgia after the rash has completely subsided, and it lasts for months or even years. The author in clinical practice, the use of antiviral drugs and early application of glucocorticoids and other comprehensive therapy, the treatment of herpes zoster has achieved better clinical results, is described below: 1, the use of antiviral drugs Lova As herpes zoster is caused by a virus, the treatment of the disease is focused on antiviral therapy, at present, acyclovir is the most commonly used drugs for the treatment of herpes zoster, early application can inhibit the virus and Early application can inhibit the virus and prevent its spread, thus shortening the course of the disease, reducing complications and preventing the occurrence of post-neuralgia. The conventional application of acyclovir tablets is 0.2g/dose, 5 times/day for 7-10 days, but there are also many data advocating the use of high dose of acyclovir tablets 0.8g/dose, 5 times/day for 7-10 days, which can significantly shorten the course of the disease, reduce complications and prevent the occurrence of posterior neuralgia compared with the conventional application dose, and the difference is statistically significant. The author believes that the high-dose application of acyclovir must be beware of the occurrence of adverse reactions. In addition, the routine application of the new generation of broad-spectrum anti-herpes viral drugs vaxilovir and famciclovir has satisfactory efficacy in preventing the occurrence of post-herpetic neuralgia. Early application of glucocorticoids Glucocorticoids have an anti-inflammatory effect on inflammation caused by infection, and can improve the symptoms of redness, swelling and pain in the early stages of inflammation, and inhibit tissue proliferation in the later stages to prevent adhesions and scar formation. Early application (within 1 week of onset) for herpes zoster can reduce edema of diseased nerve tissues, avoid or reduce inflammatory adhesions and fiber wrapping of nerve tissues, and eliminate or reduce the occurrence of post-neuralgia. Generally, prednisone 20~45mg/day is applied, divided into 3 oral doses for 1 week. It is worth noting that the application of glucocorticosteroids can reduce the immune function of the body, and may cause the rash to spread widely, so the clinical application should strictly control the indications of glucocorticosteroids. 3, the joint application of semiconductor laser semiconductor laser irradiation is through the biological and thermal effects of low-power laser, enhance the body’s immunity, promote the absorption of inflammation, reduce edema, the repair and regeneration of traumatic tissue are very good effect. At the same time, it can reduce the chemical and mechanical stimulation of nerve endings at the injury site, regulate the excitability of nerve endings, enhance cellular vitality, promote metabolism, improve local tissue nutrition, and facilitate the growth and functional recovery of nerve cells, thus achieving anti-inflammatory, swelling and analgesic effects. Each irradiation for 15 minutes for 7 to 14 days will have a very significant effect. In addition, on the basis of the above treatment, according to the patient’s condition and needs, Chinese herbal medicine therapy, acupuncture therapy, immunotherapy, and closure therapy can also be used, all of which can help shorten the course of the disease and reduce or eliminate the occurrence of postherpetic neuralgia.