1.Menarche before the age of 12 or menopause later than 50 years old. 2.Celibate and infertile or infertile after marriage, married and childbearing but have not breast-feeding. 3.Repeated abortions. 4.Use of hormonal drugs or cosmetics. 5.Family history of breast cancer. 6. Obesity or excessive fat intake. 7.Mental depression, frequent anger and bad mood. 8, Repeated long-term exposure to various kinds of radiation (multiple radiation, computer, cell phone, etc.).