Multiple nodular foci in both lungs are usually detected by chest imaging, which is common in chronic smoking, bronchodilatation with infections, or long-term exposure to dust such as stonemasons, coal miners and other specialties, and can also occur in pneumonias caused by Staphylococcus aureus infections in both lungs, which cause multiple nodular changes in both lungs due to toxin destruction after resorption. Many autoimmune diseases, including Wegener’s granulomatosis, systemic lupus erythematosus, and rheumatoid arthritis, can also present in the late stages of fibrotic foci in both lungs, accompanied by multiple nodular foci in both lungs. Pathologic puncture examination given is mostly suggestive of inflammatory granulomatous changes, but on imaging it will suggest multiple nodular foci of changes in both lungs, so CT finding of multiple nodular foci in both lungs requires further clarification of whether it is inflammatory, neoplastic, tuberculous, or autoimmune disease. If there is a malignant tendency, further fiberoptic bronchoscopy and alveolar lavage need to be given to check for tumor cells so that early antitumor therapy can be given to avoid missed diagnosis and misdiagnosis.