Polypoid lesions of the gallbladder (PLG) are a general term for a group of non-stones-like lesions in which the wall of the gallbladder bulges into the cystic cavity in a polyp-like fashion, also known as gallbladder bulge-like lesions. The classification of PLG has not been fully standardized. According to the number of lesions, they are divided into single polyps and multiple polyps; according to the location of lesions, they are divided into polyps at the neck, body and base of the gallbladder; according to the Christensen pathological classification criteria in 1970, they are divided into benign pseudotumors and true tumors; currently, the more widely used classification is non-neoplastic and neoplastic, and the latter is divided into benign and malignant. The key to treatment is to distinguish neoplastic from non-neoplastic PLG, and the risk factors for neoplastic PLG are generally considered to be: ① solitary; ② lesion diameter ≥ 10 mm; ③ lesion located in the neck of gallbladder; ④ wide base or thick tip; ⑤ combined with gallstones; ⑥ CFDI shows abundant blood flow; ⑦ age > 60 years. Most scholars believe that surgery should be actively performed in the following cases: ① high suspicion of neoplastic PLG; ② significant clinical symptoms; ③ significant enlargement of the lesion in a short period of time.