Grade III breast cancer is usually combined with lymph node metastasis in the axilla, as well as metastasis to the supraclavicular or parasternal lymph nodes. For axillary lymph nodes, they may appear to be fused and have significant localized pain with numbness in the upper extremities, or in severe cases, edema in the upper extremities. The development of tumor may also involve the subcutaneous lymphatic vessels, manifesting as orange peel-like changes in the breast skin. If the breast ducts are involved, the tumor may also show local dimple sign, and the surface of the tumor is not smooth, poorly defined and immobile, and may even invade the pectoralis major muscle fascia. For grade III breast cancer, preoperative neoadjuvant therapy should be selected and evaluated again, and radical resection surgery can be chosen for treatment after the descending stage. After surgery, additional intravenous chemotherapy as well as radiation therapy is required, as well as long-term endocrine therapy.