Whether Stage 2 membranous nephropathy can affect life expectancy mainly depends on the effectiveness of its treatment and complications. If the treatment effect is good, it usually does not affect the life expectancy; if the treatment effect is poor, leading to disease progression and eventually developing into end-stage renal disease, it may affect the life expectancy. Membranous nephropathy stage II belongs to one kind of nephrotic syndrome, and its treatment mainly consists of hormone plus immunosuppressant, and the most commonly used treatment is hormone combined with cyclophosphamide, and drugs such as tacrolimus capsule, cyclosporine capsule and moratorium mescaline capsule can be applied as well. If the patient’s treatment effect is good. The disease may be relieved and cured, and life expectancy is not affected at this time. If the patient’s treatment effect is not good, especially coupled with a series of triggers such as fatigue, low immunity or upper gastrointestinal tract infection, which leads to disease progression and eventually develops into end-stage renal disease, at this time, life expectancy may be affected. All of the above medications should be used under the guidance of a doctor, avoid self-medication. For patients with membranous nephropathy stage 2, it is recommended to go to regular hospitals in time and give targeted treatment or therapy under doctor’s guidance.